Again bottling up promising research...


Just as in the case of thymidine (see posts 40 and 41 in the series “Dictatorship USA – A Personal History,” there was no chance that my scientific work at the All-Union/Russian Cancer Center would be utilized by other researchers, developed further or employed in treating cancer patients.


It cannot be excluded that these publications would have lain fallow in any case, but in my situation the CIA/KGB/FSB made sure that no one would touch my scientific labors. A summary of that work and its potential importance follows.


Practical method for testing potential anticancer drugs on human tumors in vivo#...


Preclinical testing of the effectiveness of anticancer drugs in vivo remains an important priority in developing improved therapies for oncological illnesses. Evaluation of drug activity against human tumors is far preferable to using murine (mouse) tumors, as the latter often do not predict for clinical efficacy, while the results of drug test against human cancers implanted in nude or immunosuppressed mice have demonstrated good correlation with the treatment of patients.


Measuring the growth inhibition of human tumors implanted in the subrenal capsule (SRC) of nude mice provides a quantitative method of determining actual anticancer drug results. However, the expense and labor required for maintaining pathogen-free nude mice colonies have seriously restricted the feasibility of conducting large-scale screening with these animals.


In unmanipulated immunocompetent mice, the large and rapid infiltration of host cells following xenotransplantation of human cancers makes it virtually impossible to reliably estimate antitumor drug effect, and this approach therefore has been largely abandoned.


Studies in my laboratory at the Cancer Center in Moscow showed that human tumors can be serially passaged in the SRC of normal mice immunosuppressed with a single dose of non-lethal whole-body irradiation. In these animals the antitumor activity of standard doses of anticancer agents can be readily determined##,###.


Using genetically immunocompetent mice as human tumor hosts would greatly lower the expense of and would facilitate the wide-range and intensive pre-clinical testing of new drugs.

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Moreover, it cannot be excluded that the methodology developed in my laboratory could be extended and further refined to routinely assessing the anticancer activity of established (and new) agents against patients' tumors after surgical excision. Even in nude mice, many human tumor specimens obtained after surgery have not been found to proliferate well in the SRC or in other body sites and therefore could not serve to routinely evaluate anticipated antitumor activity for patients.


The simple and practicable method I developed could be well adapted to exploring approaches to enhancing the attachment and growth of human surgical specimens in the SRC (or elsewhere), possibly by enhancing immunosuppression with allogenic or xenogenic liver tissue#### or with other agents (including those which might enhance biological attachment of the excised tumor specimen to host tissue, stimulate angiogenesis, etc.).


Successful efforts along these lines would constitute a practical method of custom-designing post-operative therapy for individual patients, thus sparing unneeded toxicity##### and prolonging life or even curing the stricken individual.


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The advantages are obvious of pursuing the lines of research I developed. Yet nothing further has been done and there is no obvious perspective that this work will be followed up. Especially as the CIA/FSB ordered that I be fired without cause at the Cancer Center in Moscow (see next post).

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# A process taking place in a living organism.

## A.Lockshin et al., A simple method for testing sensitivity of human tumors to antitumor agents in vivo, Bulletin of Experimental Biology and Medicine 112(4):1501-1504 · October 1991 (also in Russian: Бюлл. Экспер. Биол. 1991 № 10, С.428-430)

### V.I Ryabkova, A.Lockshin et al., Testing prospective anticancer drugs against human tumors using simple in vivo models, Oncology 51, 540-543 (1994)

#### V.I Ryabkova, et al., Growth of human tumor xenografts after inoculation of liver tissue into immunocompetent mice, Вестник ОНЦ АМИ России 1993 № 4, С. 14-17 (in Russian and in English)

##### “One of the characteristics that distinguish anticancer agents from other drugs is the frequency and severity of side effects at therapeutic doses... The side effects may be acute or chronic, self-limited, permanent, mild or potentially life threatening. Management of these side effects is of utmost importance because they affect the treatment, tolerability and overall quality of life.” (Toxicities of anticancer drugs and its management, International Journal of Basic and Clinical Pharmacology, 1, № 1, 2-12, 2012)



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Перед нами сейчас - коварный и опасный мошенник, расист, лжец и фашист Дональд Трамп, порочный Конгресс, нацистские ФБР - ЦРУ, кровавые милитаристы США и НАТО >>> а также и лживые, вредоносные американские СМ»И».

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Правительство США жестоко нарушало мои права человека при проведении кампании террора, которая заставила меня покинуть свою родину и получить политическое убежище в СССР. См. книгу «Безмолвный террор — История политических гонений на семью в США» - "Silent Terror: One family's history of political persecution in the United States» - arnoldlockshin.wordpress.com


Правительство США еще нарушает мои права, в течении 14 лет отказывается от выплаты причитающейся мне пенсии по старости. Властители США воруют пенсию!!


ФСБ - Федеральная служба «безопасности» России - вслед за позорным, предавшим страну предшественником КГБ, выполняет приказы секретного, кровавого хозяина (boss) - американского ЦРУ (CIA). Среди таких «задач» - мне запретить выступать в СМИ и не пропускать большинства отправленных мне комментариев. А это далеко не всё...


Арнольд Локшин, политэмигрант из США



BANNED – ЗАПРЕЩЕНО !!

ЦРУ - ФСБ забанили мои посты и комментарии в Вконтакте!
… и в Макспарке!